The Challenge in Combining Pelotherapy and Electrotherapy (Iontophoresis) in One Single Therapeutic Modality

Pelotherapy and electrotherapy are therapeutic methodologies with proven success in physical medicine rehabilitation (PMR) dermatology fields. The main purpose of these modalities is to reduce pain, accelerate wound healing, alleviate muscle spasms, improve mobility, tone. Their challenge the passage some ionic species through skin barrier. use drugs, such as diclofenac, corticosteroids or steroids, has gained widespread efficacy recognition therapy action drugs widely studied experimental clinical trials. Unlike pharmaceutical cosmetic clays, peloids not subject any prior quality control specific European regulation. dermal absorption values an integral part risk assessment process for peloids. This work explores converging points between two transdermal drug delivery systems (TDDS) presentation achieve peloid safety compliance, especially concerning potential degree toxicity arising from ion exchange trace elements. TDDS applied pharmaceuticals industry generic term active substances released into tissues. clay components properties limited due excellent barrier function stratum corneum. pelotherapy enhanced by temperature electrically iontophoresis. low voltage iontophoresis sweat phenomena pore dilation driven allows same pathways: hair follicles pore. integration focused on patient benefits safety-related may contribute outstanding physiological performance pelotherapy, specifically, way essential elements cations pass validation innovative iontophoretic can also promote future challenges obtaining ideal results recognition.